Running title: B. ANTHRACIS SPORE CORTEX LYTIC ENZYMES
نویسندگان
چکیده
13 Correspondent footnote: 14 Department of Biological Sciences 15 Virginia Tech 16 Life Sciences I MC0910 17 Washington St. 18 Blacksburg, VA 24061 19 Phone: (540) 231-2529. Fax: (540) 231-4043. E-mail: [email protected] 20 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.01380-09 JB Accepts, published online ahead of print on 4 December 2009
منابع مشابه
Cortex peptidoglycan lytic activity in germinating Bacillus anthracis spores.
Bacterial endospore dormancy and resistance properties depend on the relative dehydration of the spore core, which is maintained by the spore membrane and its surrounding cortex peptidoglycan wall. During spore germination, the cortex peptidoglycan is rapidly hydrolyzed by lytic enzymes packaged into the dormant spore. The peptidoglycan structures in both dormant and germinating Bacillus anthra...
متن کاملContributions of four cortex lytic enzymes to germination of Bacillus anthracis spores.
Bacterial spores remain dormant and highly resistant to environmental stress until they germinate. Completion of germination requires the degradation of spore cortex peptidoglycan by germination-specific lytic enzymes (GSLEs). Bacillus anthracis has four GSLEs: CwlJ1, CwlJ2, SleB, and SleL. In this study, the cooperative action of all four GSLEs in vivo was investigated by combining in-frame de...
متن کاملThe Bacillus anthracis SleL (YaaH) protein is an N-acetylglucosaminidase involved in spore cortex depolymerization.
Bacillus anthracis spores, the infectious agents of anthrax, are notoriously difficult to remove from contaminated areas because they are resistant to many eradication methods. These resistance properties are due to the spore's dehydration and dormancy and to the multiple protective layers surrounding the spore core, one of which is the cortex. In order for B. anthracis spores to germinate and ...
متن کاملRole of YpeB in cortex hydrolysis during germination of Bacillus anthracis spores.
The infectious agent of the disease anthrax is the spore of Bacillus anthracis. Bacterial spores are extremely resistant to environmental stresses, which greatly hinders spore decontamination efforts. The spore cortex, a thick layer of modified peptidoglycan, contributes to spore dormancy and resistance by maintaining the low water content of the spore core. The cortex is degraded by germinatio...
متن کاملRoles of germination-specific lytic enzymes CwlJ and SleB in Bacillus anthracis.
The structural characteristics of a spore enable it to withstand stresses that typically kill a vegetative cell. Spores remain dormant until small molecule signals induce them to germinate into vegetative bacilli. Germination requires degradation of the thick cortical peptidoglycan by germination-specific lytic enzymes (GSLEs). Bacillus anthracis has four putative GSLEs, based upon sequence sim...
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